Research Tech II -Mitochondrial Medicine Research Group Laboratory

Dr. Falk's research laboratory at The Children’s Hospital of Philadelphia Research Institute was established in 2006 and is focused in researching the mechanisms underlying disease, and potential novel therapies, for mitochondrial respiratory chain diseases. The laboratory primarily uses human cell, C. elegans (worm), zebrafish, small animal models, and occasionally mouse models for these purposes.

We have a position open immediately for a research technician to join the group to investigate the therapeutic mechanisms of primary mitochondrial disease through whole-animal behavioral phenotyping and mitochondrial physiology studies, as well as assisting in the evaluation of the efficacy and toxicity of pharmacologic agents in both cell and animal models of primary mitochondrial respiratory chain diseases. This work involves analyses of candidate therapies and high-throughput drug screening, with both academic and pharma partners.     

 

Prior experience is highly desirable in performing translational investigations in C. elegans (worm), zebrafish, and/or human cell culture, working with pharmacologic agents, microscopy, flow sorting, and standard molecular laboratory investigations including gene expression profiling, cell sorting analyses, gene sequencing, and western blot analyses. Experience performing high-throughput drug screening in cells and animal models is strongly preferred. Experience with mitochondrial models or physiology investigations and/or training in pharmacology is highly desirable. The successful applicant will be a team player, work independently but with regular communication with the PI and study team, have strong data analysis skills including in Excel, Prism, ImageJ, and Matlab, excellent organization skills, be a quick learner, be highly attentive to detail, have excellent communication skills, and be able to make a 2 year commitment to this research

• Bachelor’s degree required

• Minimum 18 months relevant laboratory experience required.

 

To learn more about this lab: